Serological Evidence of Herpes Simplex Virus-1 (HSV-1) Infection among Humans from Bandung, West Java Province, Indonesia

BACKGROUND: Toxoplasma gondii, Rubella virus, Cytomegalovirus, and herpes simplex virus (TORCH) infection is still a significant burden in developing countries since they potentially increase perinatal death decrease life quality by causing congenital disorders. As part of TORCH as one the most common infections humans, HSV Type 1 also should receive attention. HSV-1 induces an immediate reactive oxygen species (ROS) production, indicate that ROS plays beneficial effects several biological functions, including innate immunity antiviral responses. preferentially replicate establish latency different subtypes sensory neurons autonomic nervous system are highly responsive to stress hormones, cortisol. AIM: The objective study was detect latent adults population its effect on cortisol levels. PATIENTS AND METHODS: Subjects were enrolled with consecutive-sampling methods among age 18–40 years old, no health complaints. We collected their blood examined IgG HSV-1, ROS, RESULTS: A total 57 subjects 27 (herpes group) 30 non-reactive (non groups). Mean 223.2904 nmol/L 2.23337 IU/mL, respectively. There very weak correlation between CONCLUSION: positive adult